G-Protein Computer Animation

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Summary

Description	This dynamic illustration (animation) of the Signal Transduction idea represents Martin Rodbell's revolutionary concept of how cells sense their environment. The small red spheres represent the extracellular signals such as hormones, growth factors, cytokines, odorants, taste molecules, ions, light, etc. The large green sphere represents the receptor that discriminates and binds extracellular signals. The yellow represents the transducer (G-protein), which not only affects the binding properties of the receptor to extracellular signals, but also is required for activation (or, in some cases, inhibition not represented here) of a target protein known as the effector (green) such as adenylyl cyclase. This concept is still unchallenged, despite of being more than three decades old. It represents a departure from the model proposed by Dr. Earl Sutherland, suggesting that the enzyme adenylyl cyclase was both a receptor and an effector for extracellular signals (wire framed green bullet, jus
Source	collections.nlm.nih.gov
Author	Ribeiro, Cassio, Ribeiro-Neto, Fernando

Public Domain

Attribution: Ribeiro, Cassio, Ribeiro-Neto, Fernando